Share

News & Articles

General Vaccine Safety Studies


Demographic characteristics of members of the Vaccine Safety Datalink (VSD): A comparison with the United States population.

August 26, 2015

Sukumaran et al. Vaccine

The Vaccine Safety Datalink (VSD) is a collaboration between CDC and nine integrated health care systems that serves as a cornerstone of US post-licensure vaccine safety monitoring. Given concerns that potential differences between the insured VSD population and the US population could limit the generalizability of VSD study findings, this paper performed a comparison of the demographic characteristics between the two populations.



Safety of Vaccines Used for Routine Immunization of US Children: A Systematic Review.

June 1, 2014

Maglione et al. Pediatrics

Concerns about vaccine safety have led some parents to decline recommended vaccination of their children, leading to the resurgence of diseases. Reassurance of vaccine safety remains critical for population health. This study systematically reviewed the literature on the safety of routine vaccines recommended for children in the United States.



More General Vaccine


Studies about Pertussis and Tdap/DTap


Association of Tdap Vaccination With Acute Events and Adverse Birth Outcomes Among Pregnant Women With Prior Tetanus-Containing Immunizations

October 20, 2015

Sukumaran et al. JAMA

Pertussis is poorly controlled, with the highest rates of morbidity and mortality among infants. Although the source of infant pertussis is often unknown, when identified, mothers have historically been the most common reservoir of transmission. Despite high vaccination coverage, disease incidence has been increasing. The authors examined whether infant source of infection (SOI) has changed in the United States in light of the changing epidemiology.



Sources of Infant Pertussis Infection in the United States

September 1, 2015

Skoff et al. Pediatrics

Pertussis is poorly controlled, with the highest rates of morbidity and mortality among infants. Although the source of infant pertussis is often unknown, when identified, mothers have historically been the most common reservoir of transmission. Despite high vaccination coverage, disease incidence has been increasing. The authors examined whether infant source of infection (SOI) has changed in the United States in light of the changing epidemiology.



More Pertussis & Tdap/DTap


Studies Examining the Reduction of Disease Burden


Seasonal Trivalent Influenza Vaccination During Pregnancy and the Incidence of Stillbirth: Population-Based Retrospective Cohort Study

April 1, 2016

Regan et. al Clinical Infectious Diseases

Mothers who received seasonal TIV during pregnancy were significantly less likely to experience stillbirth compared with unvaccinated mothers. These results support the safety of seasonal influenza immunization during pregnancy and suggest a protective effect.



The Benefit of Early Influenza Treatment of Pregnant Women Hospitalized with Laboratory Confirmed Influenza

February 4, 2016

Oboho et al. The Journal of Infectious Diseases

Pregnant women are at higher risk for serious illness and complications, including death, from influenza. For expectant mothers hospitalized with flu, early treatment with the influenza antiviral drug oseltamivir may shorten their time in the hospital, especially in severe cases, suggests a study published in The Journal of Infectious Diseases. The findings also underscore the importance of flu vaccination for this risk group.



More on Disease Burden


Measles-Mumps-Rubella (MMR) Vaccine and Autism Studies


Autism Occurrence by MMR Vaccine Status Among US Children With Older Siblings With and Without Autism

May 21, 2015

Jain et al. JAMA

To report ASD occurrence by MMR vaccine status in a large sample of US children who have older siblings with and without ASD the authors did a retrospective cohort study using an administrative claims database associated with a large commercial health plan. Participants included children continuously enrolled in the health plan from birth to at least 5 years of age during 2001-2012 who also had an older sibling continuously enrolled for at least 6 months between 1997 and 2012.



Safety of Vaccines Used for Routine Immunization of US Children: A Systematic Review.

August 1, 2014

Maglione et al. Pediatrics

Concerns about vaccine safety have led some parents to decline recommended vaccination of their children, leading to the resurgence of diseases. Reassurance of vaccine safety remains critical for population health. This study systematically reviewed the literature on the safety of routine vaccines recommended for children in the United States.



More MMR & Autism


Thimerosal and Autism Studies


Administration of thimerosal-containing vaccines to infant rhesus macaques does not result in autism-like behavior or neuropathology

October 6, 2015

Gdad et al. PNAS

Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder. Some anecdotal reports suggest that ASD is related to exposure to ethyl mercury, in the form of the vaccine preservative, thimerosal, and/or receiving the measles, mumps, rubella (MMR) vaccine. Using infant rhesus macaques receiving thimerosalcontaining vaccines (TCVs) following the recommended pediatric vaccine schedules from the 1990s and 2008, we examined behavior, and neuropathology in three brain regions found to exhibit neuropathology in postmortem ASD brains. No neuronal cellular or protein changes in the cerebellum, hippocampus, or amygdala were observed in animals following the 1990s or 2008 vaccine schedules. Analysis of social behavior in juvenile animals indicated that there were no significant differences in negative behaviors between animals in the control and experimental groups. These data indicate that administration of TCVs and/or the MMR vaccine to rhesus macaques does not result in neuropathological abnormalities, or aberrant behaviors, like those observed in ASD.



Prenatal and Infant Exposure to Thimerosal From Vaccines and Immunoglobulins and Risk of Autism

September 13, 2010

Price et al. Pediatrics

Exposure to thimerosal, a mercury-containing preservative that is used in vaccines and immunoglobulin preparations, has been hypothesized to be associated with increased risk of autism spectrum disorder (ASD). This study was designed to examine relationships between prenatal and infant ethylmercury exposure from thimerosal-containing vaccines and/or immunoglobulin preparations and ASD and 2 ASD subcategories: autistic disorder (AD) and ASD with regression.



More Thimerosal/Autism


Institute of Medicine (IOM) Reports


Childhood Immunization Schedule and Safety: Stakeholder Concerns, Scientific Evidence, and Future Studies

January 16, 2013

The Institute of Medicine (IOM) of the National Academies

This report is the most comprehensive examination of the immunization schedule to date. The IOM committee uncovered no evidence of major safety concerns associated with adherence to the childhood immunization schedule. Should signals arise that there may be need for investigation, however, the report offers a framework for conducting safety research using existing or new data collection systems.



Adverse Effects of Vaccines: Evidence and Causality

August 25, 2011

The Institute of Medicine (IOM) of the National Academies

Using epidemiologic and mechanistic evidence, the committee developed 158 causality conclusions and assigned each relationship between a vaccine and an adverse health problem to one of four categories of causation:

  • Evidence convincingly supports a causal relationship
  • Evidence favors acceptance of a causal relationship
  • Evidence favors rejection of a causal relationship
  • Evidence is inadequate to accept or reject a causal relationship

The committee finds that evidence convincingly supports a causal relationship between some vaccines and some adverse events—such as MMR, varicella zoster, influenza, hepatitis B, meningococcal, and tetanus-containing vaccines linked to anaphylaxis. Additionally, evidence favors rejection of five vaccine-adverse event relationships, including MMR vaccine and autism and inactivated influenza vaccine and asthma episodes. However, for the majority of cases (135 vaccine-adverse event pairs), the evidence was inadequate to accept or reject a causal relationship. Overall, the committee concludes that few health problems are caused by or clearly associated with vaccines.



More IOM Reports


RECENT CONVERSATIONS

Amy Pisani @ EveryChildBy2
#DYK Latinas are the most likely of all women to get cervical cancer? Join us as we co-host #SaludTues Tweetchat 1… https://t.co/RrGdnh0qDr
Amy Pisani @ EveryChildBy2
Join the #SaludTues Tweetchat “How to Fight Cervical Cancer among Latinas” at 1p EST 1/23 with @SaludAmericahttps://t.co/q4QoNTfxic
Amy Pisani @ EveryChildBy2
What if just 2 shots could save enough people to fill a baseball stadium? Well, with #HPV #vaccine that is exactly… https://t.co/US5EJI1hgs
Amy Pisani @ EveryChildBy2
There's a reason NY requires meningococcal #vaccine! @MelodyButler @NursesWhoVax @MenBAction remind us why at… https://t.co/fo2pKdaHCN
Amy Pisani @ EveryChildBy2
RT @CDCDirector: Latest #FluView report indicates there is widespread #flu activity across the U.S., and significant flu activity is likely…
Amy Pisani @ EveryChildBy2
"Pediatricians should keep in mind that many vaccine-hesitant parents are not opposed to vaccinating their kids but… https://t.co/jV7mR3PRsl
Amy Pisani @ EveryChildBy2
For those who believe that exposing their child to a virus in hopes of developing natural immunity is somehow bette… https://t.co/NElCDPP4Iv
Amy Pisani @ EveryChildBy2
Despite the rise in parental vaccination refusals for their children, the general trend shows that close to 80% of… https://t.co/R8t9cU3ZWW
Amy Pisani @ EveryChildBy2
It's the million dollar question...How should we be dealing with #science deniers? Can we learn something from how… https://t.co/YLhnhHMa9E
Amy Pisani @ EveryChildBy2
One small victory. One patient at a time. That's how Dr. Jane Goleman hopes to see fewer lives lost to #HPV related… https://t.co/wSzlWN7zWg
Amy Pisani @ EveryChildBy2
This NY mom is not just the COO of @famfightflu but also a mom who lost her 5 yr old son to #flu. She shares her st… https://t.co/pPrAH1hgFt
Amy Pisani @ EveryChildBy2
Could there be another super #flu like the one of 1918? The possibility is worrisome to scientists. #FightFlu https://t.co/gY5Entracz
Amy Pisani @ EveryChildBy2
Samantha missed her daughter's birth because she was unconscious w/ flu. She wants expectant couples to know that… https://t.co/d7TuvjpsQH
Amy Pisani @ EveryChildBy2
With #flu activity so high people are questioning, "Is there still time to get a flu shot?" Answer: Absolutely! Flu… https://t.co/QORSarIKfn
Amy Pisani @ EveryChildBy2
This story is one of the many heartbreaking #flu stories we've heard this season, illustrating just how dangerous t… https://t.co/pWUNrK1xAx
Amy Pisani @ EveryChildBy2
Benefits to getting your child an #HPV #vaccine at age 11-12. They'll only need 2 doses vs 3, the vaccine is more e… https://t.co/pgbkONbQwH
Amy Pisani @ EveryChildBy2
If only parents knew how common #HPV infections are, they may be more inclined to prevent them. #2shots2protecthttps://t.co/kXkXxszylg
Amy Pisani @ EveryChildBy2
Two months before her death from #cervicalcancer Heather urges young women to get the #HPV #vaccine.https://t.co/fsM3ZMyXRW
Amy Pisani @ EveryChildBy2
We continue to observe racial disparities in #vaccine coverage among adults w/ whites being consistently better vac… https://t.co/6bbwl5ysIq
Amy Pisani @ EveryChildBy2
Questioning whether to get your child the #HPV #vaccine? Read this and get the facts. https://t.co/6vXJLESVQIhttps://t.co/T6wx9INCVw
Amy Pisani @ EveryChildBy2
Health Officials Confirm Case Of #Measles @IndianaUniv. We certainly hope those students are up to date on their… https://t.co/x2ZDOsuy5f
Amy Pisani @ EveryChildBy2
Questioning whether to get your child the #HPV #vaccine? Read this and get the facts. https://t.co/6vXJLESVQIhttps://t.co/sk8CAVUpxg
Amy Pisani @ EveryChildBy2
What does it take to tackle an outbreak of #hepatitis A in a community? Gary Edwards, Exec Dir of @saltlakehealth j… https://t.co/flkXwDIdZI
Amy Pisani @ EveryChildBy2
New policy in #Kentucky next school yr will require students 16 and older to have a meningococcal #vaccine booster.… https://t.co/t1eQJs3uXg
Amy Pisani @ EveryChildBy2
Get your #HPV facts straight. Download the 10 Things to Know About HPV from @StopHPVCancer at… https://t.co/1AUVp6QBMi
Amy Pisani @ EveryChildBy2
HPV can be transmitted even when an infected person has no signs or symptoms. It only takes one intimate touch to p… https://t.co/F5yMwmsLPK
Amy Pisani @ EveryChildBy2
The #Minnesota Dept of Health reports statewide cases of whooping cough are near 800. Preteens, teens & adults are… https://t.co/Js0wfRUsIv
Amy Pisani @ EveryChildBy2
Yikes! #Flu cases in some states, like #Arizona, are up more than 758% over this time last year. Please get your fl… https://t.co/8IQNemfYkf
Amy Pisani @ EveryChildBy2
What this article is saying is of no surprise. Fake news and distrust of #science could lead to global epidemics. W… https://t.co/RwIJm9ikRw
Amy Pisani @ EveryChildBy2
Children are counting on Congress to #SaveCHIP. It’s bipartisan, it works, & it must be funded. https://t.co/nWdXGWOh29
Amy Pisani @ EveryChildBy2
Here's to protecting our kids! #Maine is currently 1 of only 17 states without a #meningococcal #vaccination requir… https://t.co/Sd5bTl0kyN
Amy Pisani @ EveryChildBy2
Up to 2,000 customers of a 7-Eleven store in #Utah could have been exposed to hepatitis A - a highly contagious liv… https://t.co/SvSp3jQHBK
Amy Pisani @ EveryChildBy2
Why is CHIP important? Uninsured children are 5x more likely to have an unmet need for medical care. Congress:… https://t.co/202NdfRzat
Amy Pisani @ EveryChildBy2
CHIP is a bipartisan success story that 9 million children depend on. Families and states need stability, and what… https://t.co/RIkhJyWt7N
Amy Pisani @ EveryChildBy2
Shaundra's journey w/ HPV began at 17. Yrs later she was diagnosed w/ invasive #cervicalcancer. 20 yrs have gone by… https://t.co/IFOcG5ZfLx
Amy Pisani @ EveryChildBy2
If you don't think the #flu is dangerous, check again. Flu has killed 27 people in #California alone since Oct.… https://t.co/Jdu8MQ1qwV
Amy Pisani @ EveryChildBy2
If you're resolution is to learn more, don't miss this free online class. #education #VaccinesWork https://t.co/SnXfu3FB6H
Amy Pisani @ EveryChildBy2
Know someone with #cervicalcancer and don't know how to help them? Direct them to an online support forum and help… https://t.co/LDsk067Luo
Amy Pisani @ EveryChildBy2
In honor of #CervicalHealthMonth join @StopHPVCancer on a Twitter chat today at 1pm ET to learn more about… https://t.co/zZ0c6lTZOV
Amy Pisani @ EveryChildBy2
The #HPV #vaccine can prevent cervical #cancer, yet just 49.5% of girls have completed their shots. But it's a lack… https://t.co/ZolYkfQRlV